23 research outputs found

    Letter to Timothy Coggins regarding the Southeastern Law Librarian, June 29, 1987

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    A letter from Sally Irvin to Timothy Coggins regarding the Southeastern Law Librarian

    Evaluation of West Virginia's Mountain Health Choices: Implementation, Challenges, and Recommendations

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    Assesses the implementation of the enhanced Medicaid program for low-income families that rewards personal responsibility. Examines enrollment, education and outreach, services and benefit structure, provider understanding and participation, and outcomes

    On the attribution of meaning to the condition of infertility: An analysis of individuals\u27 and couples\u27 language behaviors

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    This study explored the meaning a diagnosis of infertility had for an individual and couple. A phenomenological, meaning-centered investigation was used that examined the language individuals used when discussing fertility difficulties. A two-stage, interpretive research design was used to ascertain the attributed meaning to a diagnosis of infertility. In the first stage of the study, the participants were asked to discuss what infertility meant to them. The composite data (language subjects used to describe their attributed meaning to their infertility condition) were analyzed using Kenneth Burke\u27s method of indexing. In the second stage of this project, subjects were asked to evaluate the results revealed through the first stage. Based on their agreement, disagreement, or qualifications, the data were analyzed for level of intersubjective agreement between spouses, gender differences, and differences in meaning attributions related to demographic factors. The two-stage methodology met the necessities for factors. The two-stage methodology met the necessities for reliability and validity. The analysis of data from both stages of investigation revealed seven conclusions: the indexing method (Burke, 1964) was a viable methodology; the two-stage interview process was a viable method for establishing reliability and validity; men and women do talk about infertility in similar terms, however, the subjective salience attributed to their words differ along gender lines; men and women use different coping strategies in an effort to reduce the stresses of the infertility situation; there is a positive relationship between degree of intersubjective agreement and couples reported marital satisfaction; the meaning attributed to the condition of infertility is not static; and the nature of the change in meanings attributed to the situation of infertility is cyclical

    ST1571 (Imatinib Mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response

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    The tyrosine kinase inhibitor STI571 (imatinib mesylate, Gleevec) is an effective treatment for chronic myeloid leukemia (CML). We examined bone marrow samples from 53 patients with CML who were receiving STI571 in 3 multicenter phase 2 trials to assess morphologic changes and cytogenetic response to this drug. In most patients with initially increased blasts, the bone marrow blast count rapidly decreased during STI571 therapy. Reductions in cellularity, the myeloid/erythroid ratio (commonly with relative erythroid hyperplasia), and reticulin fibrosis (if present pretreatment) also were seen in most patients, resulting in an appearance resembling normal marrow in many cases. Eighteen patients (34%) had some degree of cytogenetic response. Surprisingly, these striking morphologic changes occurred irrespective of any cytogenetic response to STI571. Thus, STI571 seems to affect the differentiation of CML cells in vivo, causing even extensively Philadelphia chromosome-positive hematopoiesis to exhibit features resembling normal hematopoiesis. <br/

    Walrasian Economics in Retrospect

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    Two basic tenets of theWalrasian model, behavior based on self-interested exogenous preferences and complete and costless contracting have recently come under critical scrutiny. First, social norms and psychological dispositions extending beyond the selfish motives of Homo economicus may have an important bearing on outcomes, even in competitive markets. Second, market outcomes depend on strategic interactions in which power in the political sense is exercised. It follows that economics must become more behavioral and more institutional. We can return to these themes of the classical tradition, now equipped with more the powerful mathematical tools developed over the past century
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